DESIGN AND RESEARCH OF CLEARING-SETTLEMENT PLATFORM BASED ON BLOCKCHAIN TECHNOLOGY


CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway

Abstract Cancer-associated fibroblasts (CAFs) are the most abundant stromal components in the tumor microenvironment (TME) and closely involved in tumor progression.However, the precise biological functions and molecular mechanisms of CAFs in the TME have yet to be understood.Here, we demonstrate that WEE2-AS1 is highly expressed in the CAF-derived

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Erosive arthritis and hepatic granuloma formation induced by peptidoglycan polysaccharide in rats is aggravated by prasugrel treatment.

Administration of the thienopyridine P2Y12 receptor antagonist, clopidogrel, increased the erosive arthritis induced by peptidoglycan polysaccharide (PG-PS) in rats or by injection of the arthritogenic K/BxN serum in mice.To determine if the detrimental effects are caused exclusively by clopidogrel, we evaluated prasugrel, a third-generation thieno

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